Vertex Summer 2026 Intern, Preclinical Modeling and Simulation, DMPK
Vertex is a global biotechnology company that invests in scientific innovation, and they are seeking a Summer 2026 Intern for their Preclinical Modeling and Simulation team. The intern will work on developing mechanistic and systems-based models of diseases for translational research purposes, gaining meaningful experience in Drug Metabolism Pharmacokinetics functional areas.
Responsibilities
- Develop and implement quantitative systems pharmacology (QSP) models of relevant diseases in collaboration with the pM&S team
- Source modeling techniques and approaches from literature sources or design novel models as necessary to address questions and inform decision making across programs
- Collect relevant data from published sources as necessary for model calibration
- Present and discuss research progress with the pM&S team, DMPK, and other stakeholders as appropriate
Skills
- Enrolled in a graduate program, majoring in Applied Mathematics, Computational Biology, Pharmaceutical Sciences, Chemical Engineering, or a related field of study
- Significant experience (2-4 years minimum) using a programming language such as Matlab, Python, R, or Julia to numerically solve systems of ordinary differential equations is required for this position
- Experience designing and implementing ordinary differential equation-based models of biological systems, including parameter optimization using time-series data
- Experience importing, processing, and visualizing data using one of the programming languages listed above
- History of publication and/or conference presentations in mathematical biology, quantitative pharmacology, or QSP
- Legal authorization to work in the United States, now and in the future. Please note that Vertex does not provide sponsorship for internships or entry level roles within this part of the organization
- You must be enrolled in an advanced degree program if graduating before August 2026
- You must be available to work full-time, 40 hours per week from May – August 2026
- Knowledge of pharmacokinetics (PK), pharmacokinetic-pharmacynamic (PKPD) modeling, QSP, population pharmacokinetics (popPK), or graduate coursework in applied mathematics is desirable but not required
- Knowledge of modeling softwares commonly used in the pharmaceutical industry such as Phoenix WinNonlin, SimBiology, SimCyp, or MonolixSuite is desirable but not required
- Expertise in at least one specific disease area is desirable but not required
Benefits
- Free 24/7 onsite gym access and free access to group exercise classes
- Subsidized commuter benefits- transit and parking
- Provided meals—free breakfast daily!
- Career development opportunities and events, including C Suite engagement
- Social events—both intern-only and company-wide
- Location-specific perks and extras!
- Recognition of National Intern Day
- Medical, dental and vision benefits
- Generous paid time off (including a week-long company shutdown in the Summer and the Winter)
- Educational assistance programs including student loan repayment
- A generous commuting subsidy
- Matching charitable donations
- 401(k) and so much more
Company Overview